Article
Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts.
Nature communications - 7 Oct 2014
Fan Shufang, Hatta Masato, Kim Jin Hyun, Halfmann Peter, Imai Masaki, Macken Catherine A, Le Mai Quynh, Nguyen Tung, Neumann Gabriele, Kawaoka Yoshihiro
Abstract excerpt
Highly pathogenic avian H5N1 influenza viruses have sporadically transmitted to humans causing high mortality. The mechanistic basis for adaptation is still poorly understood, although several residues in viral protein PB2 are known to be important for this event. Here, we demonstrate that three residues, 147T, 339T and 588T, in PB2 play critical roles in the virulence of avian H5N1 influenza viruses in a...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.