Article

A species-specific signature residue in the PB2 subunit of the bat influenza virus polymerase restricts viral RNA synthesis

2021-04-13

Abstract excerpt

Bat influenza A viruses (H17N10 and H18N11) are genetically distant from conventional influenza A viruses and replicates poorly in non-bat hosts species. However, the reason behind the lower replication fitness of these viruses are yet to be elucidated. In this work, we have identified species-specific signature residues, present in viral PB2 protein, which is a major determinant of polymerase fitness in human, av...

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Literature Corpus work: 1567fbc1-2fa6-51c0-86ab-8d96c3c60456
DOI: 10.1101/2021.04.12.439585

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A species-specific signature residue in the PB2 subunit of the bat influenza virus polymerase restricts viral RNA synthesisDOI 10.1101/2021.04.12.439585Read

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