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Article

PB2 mutations D701N and S714R promote adaptation of an influenza H5N1 virus to a mammalian host.

Journal of virology - 1 Aug 2014

Czudai-Matwich Volker, Otte Anna, Matrosovich Mikhail, Gabriel Gülsah, Klenk Hans-Dieter

Abstract excerpt

UNLABELLED: Mutation D701N in the PB2 protein is known to play a prominent role in the adaptation of avian influenza A viruses to mammalian hosts. In contrast, little is known about the nearby mutations S714I and S714R, which have been observed in some avian influenza viruses highly pathogenic for mammals. We have generated recombinant H5N1 viruses with PB2 displaying the avian signature 701D or the mammalian...

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Identifiers

PMID: 24899203
DOI: 10.1128/JVI.00422-14
PMCID: PMC4136279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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