Article
V292I mutation in PB2 polymerase induces increased effects of E627K on influenza H7N9 virus replication in cells.
Virus research - 2 Jan 2021
Zhou Yuqing, Wu Xiaoxin, Yan Danying, Chen Can, Liu Xiaoxiao, Huang Chenyang, Fu Xiaofang, Tian Guo, Ding Cheng, Wu Jie, Xu Jia, Li Lanjuan, Yang Shigui
Abstract excerpt
Characterization of host adaptation markers among human isolates is important for recognizing the potential for cross-species transmission in avian influenza A viruses. Here, we studied two new potential adaptive mutations, V292I and D740A, in the PB2 protein that were identified by a multi-factor regression model. The study shows that the prevalence of the PB2-V292I mutation is increased in H7N9 influenza...
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