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Zebrin II expressing Purkinje cell phenotype-related and -unrelated cerebellar abnormalities in Cav2.1 mutant, rolling mouse Nagoya.

TheScientificWorldJournal - 12 Oct 2010

Sawada Kazuhiko, Fukui Yoshihiro

Abstract excerpt

Rolling mouse Nagoya is an ataxic mutant mouse that carries a mutation in a gene encoding for the alpha 1A subunit of the voltage-gated P/Q-type Ca2+ channel (Cav2.1). This report summarizes our studies and others concerning cerebellar abnormalities in rolling mice based on chemical neuroanatomy. While there are no obvious cerebellar deformations in this mutant mouse, the altered functions of Purkinje cells can...

Topics

Animals
Ataxia
Calcium Channels, N-Type
Cerebellum
Mice
Mice, Neurologic Mutants
Nerve Tissue Proteins
Phenotype
Purkinje Cells
Ryanodine Receptor Calcium Release Channel
Tyrosine 3-Monooxygenase

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Identifiers

PMID: 20953553
DOI: 10.1100/tsw.2010.205
PMCID: PMC5763974

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