Article
Genetic Architectures of Quantitative Variation in RNA Editing Pathways.
Genetics - 1 Feb 2016
Gu Tongjun, Gatti Daniel M, Srivastava Anuj, Snyder Elizabeth M, Raghupathy Narayanan, Simecek Petr, Svenson Karen L, Dotu Ivan, Chuang Jeffrey H, Keller Mark P, Attie Alan D, Braun Robert E, Churchill Gary A
Abstract excerpt
RNA editing refers to post-transcriptional processes that alter the base sequence of RNA. Recently, hundreds of new RNA editing targets have been reported. However, the mechanisms that determine the specificity and degree of editing are not well understood. We examined quantitative variation of site-specific editing in a genetically diverse multiparent population, Diversity Outbred mice, and mapped polymorphic...
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