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Article

Rapamycin Partially Reverts Cavernoma Endothelial Cell Phenotype and, When Combined With Lapatinib, Ameliorates Chronic Lesions.

Journal of cellular and molecular medicine - 1 Jul 2026

García-Colomer Mar, Martínez José E, Díaz-Gómez Luis, Sartages Miriam, Esquinas-Román Eva M, Riobello Cristina, Martínez-Delgado David, González-Pérez Diego, Gómez-Durán Aurora, Fidalgo Miguel, Varela-Rey Marta, Pombo Celia M, Zalvide Juan

Abstract excerpt

This study investigates the impact of rapamycin and propranolol on cerebral cavernous malformations (CCMs). Employing an unbiased transcriptomic analysis, we aimed to comprehensively elucidate the molecular mechanisms underlying these drug effects. Mouse Brain Microvascular Endothelial Cells (mBMEC) deficient in Ccm3 were treated with propranolol or rapamycin and were analysed by RNA-seq and immunofluorescence....

Topics

Animals
Sirolimus
Lapatinib
Endothelial Cells
Mice
Hemangioma, Cavernous, Central Nervous System
Phenotype
Mice, Knockout
Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Open in PubMed Open full text

Identifiers

PMID: 42427156
DOI: 10.1111/jcmm.71280
PMCID: PMC13351306

Genes

KLF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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