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Article

Structure and vascular function of MEKK3–cerebral cavernous malformations 2 complex

3 Aug 2015

Abstract excerpt

Cerebral cavernous malformations 2 (CCM2) loss is associated with the familial form of CCM disease. The protein kinase MEKK3 (MAP3K3) is essential for embryonic angiogenesis in mice and interacts physically with CCM2, but how this interaction is mediated and its relevance to cerebral vasculature are unknown. Here we report that Mekk3 plays an intrinsic role in embryonic vascular development. Inducible endothelial...

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PMID: 26235885
DOI: 10.1038/ncomms8937

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