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Article

The protein arginine methyltransferase PRMT6 inhibits HIV-1 Tat nucleolar retention.

Biochimica et biophysica acta - 1 Feb 2016

Fulcher Alex J, Sivakumaran Haran, Jin Hongping, Rawle Daniel J, Harrich David, Jans David A

Abstract excerpt

The human immunodeficiency virus (HIV)-1 transactivator protein Tat is known to play a key role in HIV infection, integrally related to its role in the host cell nucleus/nucleolus. Here we show for the first time that Tat localisation can be modulated by specific methylation, whereby overexpression of active but not catalytically inactive PRMT6 methyltransferase specifically leads to exclusion of Tat from the...

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Source

Identifiers

PMID: 26611710
DOI: 10.1016/j.bbamcr.2015.11.019

Genes

PRMT6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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