Article
The association of HIV-1 Tat with nuclei is regulated by Ca2+ ions and cytosolic factors.
The Journal of biological chemistry - 25 Apr 1997
Morgavi P, Bonifaci N, Pagani M, Costigliolo S, Sitia R, Rubartelli A
Abstract excerpt
Human immunodeficiency virus-1 (HIV-1) Tat, a nuclear transcription factor, has been shown to function extracellularly, implying that some Tat molecules escape nuclear import and are secreted. This raises the question of what regulates, in HIV-1-infected cells, the nuclear targeting of the polypeptide. Here we show that cytosolic components activated by Ca2+ ions are required to reveal the karyophilic properties...
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