Article
Association of functional polymorphisms of the transforming growth factor B1 gene with survival and graft-versus-host disease after unrelated donor hematopoietic stem cell transplantation.
Haematologica - 1 Feb 2010
Berro Mariano, Mayor Neema P, Maldonado-Torres Hazael, Cooke Louise, Kusminsky Gustavo, Marsh Steven G E, Madrigal J Alejandro, Shaw Bronwen E
Abstract excerpt
BACKGROUND: Many genetic factors play major roles in the outcome of hematopoietic stem cell transplants from unrelated donors. Transforming growth factor beta1 is a member of a highly pleiotrophic family of growth factors involved in the regulation of numerous immunomodulatory processes. DESIGN AND METHODS: We investigated the impact of single nucleotide polymorphisms at codons 10 and 25 of TGFB1, the gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.