Article
RAGE and CYBA polymorphisms are associated with microalbuminuria and end-stage renal disease onset in a cohort of type 1 diabetes mellitus patients over a 20-year follow-up.
Acta diabetologica - 1 Jun 2016
Franko Benoit, Benhamou Pierre-Yves, Genty Céline, Jouve Thomas, Nasse Laure, Rzeoecki Vincent, Semeraro Paul, Stasia Marie José, Zaoui Philippe
Abstract excerpt
AIMS: We investigated the association of polymorphisms of three genes implicated in oxidative stress: CYBA C242T, RAGE -374T/A and -429T/C, and ALOX12 Arg261Gln, with the delay of microalbuminuria onset in patients with type 1 diabetes mellitus (DT1). METHODS: A total of 162 T1D patients presenting with diabetes for 32.9 ± 9 years were included in the study; 53 had persistent microalbuminuria (>30 mg/l) and 109...
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