Article
Advanced glycation end products as environmental risk factors for the development of type 1 diabetes.
Current drug targets - 1 Apr 2012
Yap Felicia Y T, Kantharidis Phillip, Coughlan Melinda T, Slattery Robyn, Forbes Josephine M
Abstract excerpt
The globally rising incidence of Type 1 diabetes (T1D) is no longer restricted to individuals with higher risk genotypes, but is now significantly increasing in a population with lower risk genotypes, likely as the result of environmental factors. In this review, we discuss the potential of advanced glycation end products (AGEs) as environmental contributors to the development of T1D. AGEs are nonenzymatically...
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