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Article

Melanomas of unknown primary frequently harbor TERT-promoter mutations.

Melanoma research - 1 Apr 2014

Egberts Friederike, Krüger Sandra, Behrens Hans M, Bergner Inka, Papaspyrou Giorgios, Werner Jochen A, Alkatout Ibrahim, Haag Jochen, Hauschild Axel, Röcken Christoph

Abstract excerpt

Commonly, in patients with melanoma metastases of an unknown primary tumor (MUP), an extensive search for the primary tumor is carried out. Recently, highly recurrent telomerase reverse transcriptase (TERT)-promoter mutations were found in malignant melanomas, which may function as driver mutations of skin cancer. The aim of this study was to test the hypothesis that MUP and mucosal melanomas harbor different...

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Source

Identifiers

PMID: 24463461
DOI: 10.1097/CMR.0000000000000048

Genes

TERT
BRAF
NRAS
KIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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