Article
Prognostic impact and concordance of TERT promoter mutation and protein expression in matched primary and metastatic cutaneous melanoma.
British journal of cancer - 1 Jan 2018
Hugdahl Emilia, Kalvenes May Britt, Mannelqvist Monica, Ladstein Rita G, Akslen Lars A
Abstract excerpt
BACKGROUND: TERT promoter mutations are frequent in melanoma. Here we analysed the concordance and prognostic impact of TERT mutation and telomerase reverse transcriptase (TERT) protein expression in a large melanoma series. METHODS: In 194 primary nodular melanomas with 72 matched loco-regional metastases, TERT promoter mutation status was assessed by Sanger sequencing and TERT protein expression by...
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