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Article

Genetic polymorphisms of PCSK2 are associated with glucose homeostasis and progression to type 2 diabetes in a Chinese population.

Scientific reports - 26 Nov 2015

Chang Tien-Jyun, Chiu Yen-Feng, Sheu Wayne H-H, Shih Kuang-Chung, Hwu Chii-Min, Quertermous Thomas, Jou Yuh-Shan, Kuo Shan-Shan, Chang Yi-Cheng, Chuang Lee-Ming

Abstract excerpt

Proprotein convertase subtilisin/kexin type 2 (PCSK2) is a prohormone processing enzyme involved in insulin and glucagon biosynthesis. We previously found the genetic polymorphism of PCSK2 on chromosome 20 was responsible for the linkage peak of several glucose homeostasis parameters. The aim of this study is to investigate the association between genetic variants of PCSK2 and glucose homeostasis parameters and...

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Source

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Identifiers

PMID: 26607656
DOI: 10.1038/srep14380
PMCID: PMC4660384

Genes

PCSK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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