Article
M. tuberculosis T Cell Epitope Analysis Reveals Paucity of Antigenic Variation and Identifies Rare Variable TB Antigens.
Cell host & microbe - 11 Nov 2015
Coscolla Mireia, Copin Richard, Sutherland Jayne, Gehre Florian, de Jong Bouke, Owolabi Olumuiya, Mbayo Georgetta, Giardina Federica, Ernst Joel D, Gagneux Sebastien
Abstract excerpt
Pathogens that evade adaptive immunity typically exhibit antigenic variation. By contrast, it appears that although the chronic human tuberculosis (TB)-causing pathogen Mycobacterium tuberculosis needs to counter host T cell responses, its T cell epitopes are hyperconserved. Here we present an extensive analysis of the T cell epitopes of M. tuberculosis. We combined population genomics with experimental...
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