Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Negligible genetic diversity of mycobacterium tuberculosis host immune system protein targets: evidence of limited selective pressure.

Genetics - 1 May 2000

Musser J M, Amin A, Ramaswamy S

Abstract excerpt

A common theme in medical microbiology is that the amount of amino acid sequence variation in proteins that are targets of the host immune system greatly exceeds that found in metabolic enzymes or other housekeeping proteins. Twenty-four Mycobacterium tuberculosis genes coding for targets of the host immune system were sequenced in 16 strains representing the breadth of genomic diversity in the species. Of the 24...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyltransferases
Share to Amino Acid Sequence
Share to Antigens, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bacterial Proteins

Share to Glycoproteins

Share to Mycobacterium tuberculosis

Share to Sequence Homology, Amino Acid

Share to Tuberculosis

Source

Open in PubMed Open full text

Identifiers

PMID: 10790380
DOI: 10.1093/genetics/155.1.7
PMCID: PMC1461055

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Negligible genetic diversity of mycobacterium tuberculosis host immune system protein targets: evidence of limited selective pressure.PMID 10790380Read ↗

M. tuberculosis T Cell Epitope Analysis Reveals Paucity of Antigenic Variation and Identifies Rare Variable TB Antigens.Semantic proximity Read ↗

Conserved alanine rich protein Rv3878 in Mycobacterium tuberculosis contains sequence polymorphisms.Semantic proximity Read ↗

Human T cell epitopes of Mycobacterium tuberculosis are evolutionarily hyperconservedSemantic proximity Read ↗

The evolutionary landscape of the Mycobacterium tuberculosis genome.Semantic proximity Read ↗

Genetic diversity of antigens Rv2945c and Rv0309 in Mycobacterium tuberculosis strains may reflect ongoing immune evasion.Semantic proximity Read ↗

Sequence diversity in the pe_pgrs genes of Mycobacterium tuberculosis is independent of human T cell recognition.Semantic proximity Read ↗

Detecting selection using a single genome sequence of M. tuberculosis and P. falciparum.Semantic proximity Read ↗

Genomewide pattern of synonymous nucleotide substitution in two complete genomes of Mycobacterium tuberculosis.Semantic proximity Read ↗

Antigen 85 variation across lineages of Mycobacterium tuberculosis-implications for vaccine and biomarker success.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.