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Article

Emerging role of kinase-targeted strategies in chronic lymphocytic leukemia.

Hematology. American Society of Hematology. Education Program - 1 Jan 2012

Wiestner Adrian

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is a malignancy of mature B cells that depend on host factors in the tissue microenvironment for survival and proliferation. In vitro, CLL cells rapidly undergo apoptosis unless microenvironmental factors are provided that support their survival. Signaling pathways activated in the microenvironment in vivo include the B-cell receptor (BCR) and NF-κB pathways. Thus, CLL is a...

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Identifiers

PMID: 23233565
DOI: 10.1182/asheducation-2012.1.88

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BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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