Article
ORMDL3 contributes to the risk of atherosclerosis in Chinese Han population and mediates oxidized low-density lipoprotein-induced autophagy in endothelial cells.
Scientific reports - 25 Nov 2015
Ma Xiaochun, Qiu Rongfang, Dang Jie, Li Jiangxia, Hu Qin, Shan Shan, Xin Qian, Pan Wenying, Bian Xianli, Yuan Qianqian, Long Feng, Liu Na, Li Yan, Gao Fei, Zou Chengwei, Gong Yaoqin, Liu Qiji
Abstract excerpt
ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) is a universally confirmed susceptibility gene for asthma and has recently emerged as a crucial modulator in lipid metabolism, inflammation and endoplasmic reticulum (ER) stress-the mechanisms also closely involved in atherosclerosis (AS). Here we first presented the evidence of two single nucleotide polymorphisms regulating ORMDL3 expression (rs7216389 and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.