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Differential Evolution of the Epidermal Keratin Cytoskeleton in Terrestrial and Aquatic Mammals

14 Nov 2018

Abstract excerpt

Keratins are the main intermediate filament proteins of epithelial cells. In keratinocytes of the mammalian epidermis they form a cytoskeleton that resists mechanical stress and thereby are essential for the function of the skin as a barrier against the environment. Here, we performed a comparative genomics study of epidermal keratin genes in terrestrial and fully aquatic mammals to determine adaptations of the...

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PMID: 30517738
DOI: 10.1093/molbev/msy214

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