Article

Targeted adaptive sampling enables clinical pharmacogenomics testing and genome-wide genotyping

2025-05-07

Abstract excerpt

Pharmacogenomics (PGx) testing improves medication safety and efficacy by identifying genetic variants that affect drug response. However, current technologies often fail to resolve complex loci, detect structural variants, or phase alleles accurately. Here, we present an end-to-end PGx workflow based on Targeted Adaptive Sampling-Long Read Sequencing (TAS-LRS), integrating a streamlined laboratory protocol with a...

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Literature Corpus work: ea4bc3a1-4075-5f3c-97cd-8587af22f155
DOI: 10.1101/2025.05.05.25326970

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