Article
Flexible and Scalable Full-Length CYP2D6 Long Amplicon PacBio Sequencing.
Human mutation - 1 Mar 2017
Buermans Henk P J, Vossen Rolf H A M, Anvar Seyed Yahya, Allard William G, Guchelaar Henk-Jan, White Stefan J, den Dunnen Johan T, Swen Jesse J, van der Straaten Tahar
Abstract excerpt
Cytochrome P450 2D6 (CYP2D6) is among the most important genes involved in drug metabolism. Specific variants are associated with changes in the enzyme's amount and activity. Multiple technologies exist to determine these variants, like the AmpliChip CYP450 test, Taqman qPCR, or Second-Generation Sequencing, however, sequence homology between cytochrome P450 genes and pseudogene CYP2D7 impairs reliable CYP2D6...
Topics
- Cytochrome P-450 CYP2D6
- DNA Copy Number Variations
- Gene Deletion
- Gene Duplication
- Genetic Variation
- Genotype
- Humans
- Sequence Analysis, DNA
- Translocation, Genetic