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Article

Epigenetic regulation of TP53 is involved in prostate cancer radioresistance and DNA damage response signaling

16 Oct 2023

Abstract excerpt

External beam radiotherapy (RT) is a leading first-line therapy for prostate cancer (PCa), and, in recent years, significant advances have been accomplished. However, RT resistance can arise and result in long-term recurrence or disease progression in the worst-case scenario. Thus, making crucial the discovery of new targets for PCa radiosensitization. Herein, we generated a radioresistant PCa cell line, and...

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PMID: 37840069
DOI: 10.1038/s41392-023-01639-6

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