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Article

Filamenting temperature-sensitive mutant Z inhibitors from Glycyrrhiza glabra and their inhibitory mode of action.

Bioorganic & medicinal chemistry letters - 15 Mar 2017

Matsui Takashi, Lallo Subehan, Nisa Khoirun, Morita Hiroyuki

Abstract excerpt

FtsZ is an essential protein for bacterial cell division, and an attractive and underexploited novel antibacterial target protein. Screening of Indonesian plants revealed the inhibitory activity of the methanol extract of Glycyrrhiza glabra on the Bacillus subtilis FtsZ (BsFtsZ) GTPase, and further bioassay-guided fractionation of the active methanol extract led to the isolation of seven known polyketides (1-7)....

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PMID: 28196701
DOI: 10.1016/j.bmcl.2017.01.095

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