Article
The lethal effect of a benzamide derivative, 3-methoxybenzamide, can be suppressed by mutations within a cell division gene, ftsZ, in Bacillus subtilis.
Journal of bacteriology - 1 Feb 1999
Ohashi Y, Chijiiwa Y, Suzuki K, Takahashi K, Nanamiya H, Sato T, Hosoya Y, Ochi K, Kawamura F
Abstract excerpt
3-Methoxybenzamide (3-MBA), which is known to be an inhibitor of ADP-ribosyltransferase, inhibits cell division in Bacillus subtilis, leading to filamentation and eventually lysis of cells. Our genetic analysis of 3-MBA-resistant mutants indicated that the primary target of the drug is the cell d...
Topics
- Bacillus subtilis
- Bacterial Proteins
- Benzamides
- Cell Division
- Cytoskeletal Proteins
- Drug Resistance, Microbial
- Mutation
- Poly(ADP-ribose) Polymerase Inhibitors
- Sigma Factor
- Spores, Bacterial
- Suppression, Genetic
- Transcription Factors