Article
Computed Tomography (CT) Scanning Facilitates Early Identification of Neonatal Cystic Fibrosis Piglets.
PloS one - 1 Jan 2015
Guillon Antoine, Chevaleyre Claire, Barc Celine, Berri Mustapha, Adriaensen Hans, Lecompte François, Villemagne Thierry, Pezant Jérémy, Delaunay Rémi, Moënne-Loccoz Joseph, Berthon Patricia, Bähr Andrea, Wolf Eckhard, Klymiuk Nikolai, Attucci Sylvie, Ramphal Reuben, Sarradin Pierre, Buzoni-Gatel Dominique, Si-Tahar Mustapha, Caballero Ignacio
Abstract excerpt
BACKGROUND: Cystic Fibrosis (CF) is the most prevalent autosomal recessive disease in the Caucasian population. A cystic fibrosis transmembrane conductance regulator knockout (CFTR-/-) pig that displays most of the features of the human CF disease has been recently developed. However, CFTR-/- pigs presents a 100% prevalence of meconium ileus that leads to death in the first hours after birth, requiring a rapid...
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