Article
Development of a porcine model of cystic fibrosis.
Transactions of the American Clinical and Climatological Association - 1 Jan 2009
Welsh Michael J, Rogers Christopher S, Stoltz David A, Meyerholz David K, Prather Randall S
Abstract excerpt
Cystic Fibrosis (CF) is a common autosomal recessive disease that affects multiple organs. The lack of an animal model with manifestations like those typically found in humans has slowed understanding of its pathogenesis. Therefore, because of the similarities between human and swine anatomy, biochemistry, physiology, size, and genetics, we chose to develop a porcine model of CF. We used homologous recombination...
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