Article
Comparative biology of cystic fibrosis animal models.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2011
Fisher John T, Zhang Yulong, Engelhardt John F
Abstract excerpt
Animal models of human diseases are critical for dissecting mechanisms of pathophysiology and developing therapies. In the context of cystic fibrosis (CF), mouse models have been the dominant species by which to study CF disease processes in vivo for the past two decades. Although much has been learned through these CF mouse models, limitations in the ability of this species to recapitulate spontaneous lung...
Topics
- Animals
- Animals, Genetically Modified
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Disease Models, Animal
- Female
- Ferrets
- Graft Survival
- Humans
- Male
- Mice