Article
Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis.
The Laryngoscope - 1 Sept 2012
Chang Eugene H, Pezzulo Alejandro A, Meyerholz David K, Potash Andrea E, Wallen Tanner J, Reznikov Leah R, Sieren Jessica C, Karp Philip H, Ernst Sarah, Moninger Thomas O, Gansemer Nicholas D, McCray Paul B, Stoltz David A, Welsh Michael J, Zabner Joseph
Abstract excerpt
OBJECTIVES/HYPOTHESIS: Chronic sinusitis is nearly universal in humans with cystic fibrosis (CF) and is accompanied by sinus hypoplasia (small sinuses). However, whether impaired sinus development is a primary feature of loss of the cystic fibrosis transmembrane conductance regulator (CFTR) or a secondary consequence of chronic infection remains unknown. Our objective was to study the early pathogenesis of sinus...
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