Article

In Utero CFTR Modulation Alleviates Disease in G551D Cystic Fibrosis Pigs

2026-01-21

Abstract excerpt

<h4>ABSTRACT</h4> Previous studies indicate that pigs with CFTR-null and CFTR-ΔF508 mutations develop multiorgan disease similar to that in people with cystic fibrosis (CF). At birth, their airways exhibit host defense defects that predispose to airway infection, inflammation, and mucus accumulation. The CFTR-G551D mutation causes CF by producing CFTR channels that localize correctly but have reduced channel a...

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Literature Corpus work: 77c39bb4-df3e-5422-bc9d-a43d1640ecd8
DOI: 10.64898/2026.01.20.698888

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