Article
Sequential targeting of CFTR by BAC vectors generates a novel pig model of cystic fibrosis.
Journal of molecular medicine (Berlin, Germany) - 1 May 2012
Klymiuk N, Mundhenk L, Kraehe K, Wuensch A, Plog S, Emrich D, Langenmayer M C, Stehr M, Holzinger A, Kröner C, Richter A, Kessler B, Kurome M, Eddicks M, Nagashima H, Heinritzi K, Gruber A D, Wolf E
Abstract excerpt
Cystic fibrosis (CF) is the most common lethal inherited disease in Caucasians and is caused by mutations in the CFTR gene. The disease is incurable and medical treatment is limited to the amelioration of symptoms or secondary complications. A comprehensive understanding of the disease mechanisms and the development of novel treatment options require appropriate animal models. Existing CF mouse models fail to...
Topics
- Alleles
- Animals
- Cells, Cultured
- Chromosomes, Artificial, Bacterial
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Disease Models, Animal
- Fetus
- Gene Knockout Techniques