Article
Next-generation re-sequencing of genes involved in increased platelet reactivity in diabetic patients on acetylsalicylic acid.
Platelets - 1 Jun 2016
Postula Marek, Janicki Piotr K, Eyileten Ceren, Rosiak Marek, Kaplon-Cieslicka Agnieszka, Sugino Shigekazu, Wilimski Radosław, Kosior Dariusz A, Opolski Grzegorz, Filipiak Krzysztof J, Mirowska-Guzel Dagmara
Abstract excerpt
The objective of this study was to investigate whether rare missense genetic variants in several genes related to platelet functions and acetylsalicylic acid (ASA) response are associated with the platelet reactivity in patients with diabetes type 2 (T2D) on ASA therapy. Fifty eight exons and corresponding introns of eight selected genes, including PTGS1, PTGS2, TXBAS1, PTGIS, ADRA2A, ADRA2B, TXBA2R, and P2RY1...
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