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Potential of Tetracycline Resistance Proteins To Evolve Tigecycline Resistance

24 Nov 2015

Abstract excerpt

Tigecycline is a glycylcycline antibiotic active against multidrug-resistant bacterial pathogens. The objectives of our study were to examine the potential of the Tet(A), Tet(K), Tet(M), and Tet(X) tetracycline resistance proteins to acquire mutations causing tigecycline resistance and to determine how this affects resistance to earlier classes of tetracyclines. Mutations in all four tet genes caused a...

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PMID: 26596936
DOI: 10.1128/aac.02465-15

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