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Article

Association of age-of-onset groups with GWAS significant schizophrenia and bipolar disorder loci in Romanian bipolar I patients.

Psychiatry research - 30 Dec 2015

Grigoroiu-Serbanescu Maria, Diaconu Carmen C, Heilmann-Heimbach Stefanie, Neagu Ana Iulia, Becker Tim

Abstract excerpt

We investigated the influence of the age-of-onset (AO) on the association of 45 loci conferring risk for bipolar disorder (BP) and schizophrenia with BP-type-I in a Romanian sample (461 patients, 436 controls). The AO-analysis implicated the EGFR gene, as well as loci in other genes, in the AO variation of BP-type-I and revealed for the first time the link between BP-type-I and risk variants considered specific...

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Identifiers

PMID: 26596365
DOI: 10.1016/j.psychres.2015.11.008

Genes

CNNM2
EGFR
MMP16
RIPK2

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