Article
Commingling analysis of age-of-onset in bipolar I disorder and the morbid risk for major psychoses in first degree relatives of bipolar I probands.
Journal of affective disorders - 1 Oct 2014
Grigoroiu-Serbanescu Maria, Rietschel Marcella, Hauser Joanna, Czerski Piotr M, Herms Stefan, Sun Xianqing, Wickramaratne Priya, Elston Robert C
Abstract excerpt
BACKGROUND: Age-of-onset (AO) is increasingly used in molecular genetics of bipolar I disorder (BP-I) as a phenotypic specifier with the goal of reducing genetic heterogeneity. However, questions regarding the cut-off age for defining early onset (EO), as well as the number of onset groups characterizing BP-I have emerged over the last decade with no definite conclusion. The aims of this paper are: 1) to see...
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