Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Analyzing schizophrenia-related phenotypes in mice caused by autoantibodies against NRXN1α in schizophrenia.

Brain, behavior, and immunity - 1 Jul 2023

Shiwaku Hiroki, Katayama Shingo, Gao Mengxuan, Kondo Kanoh, Nakano Yuri, Motokawa Yukiko, Toyoda Saori, Yoshida Fuyuko, Hori Hiroaki, Kubota Tetsuo, Ishikawa Kinya, Kunugi Hiroshi, Ikegaya Yuji, Okazawa Hitoshi, Takahashi Hidehiko

Abstract excerpt

The molecular pathological mechanisms underlying schizophrenia remain unclear; however, genomic analysis has identified genes encoding important risk molecules. One such molecule is neurexin 1α (NRXN1α), a presynaptic cell adhesion molecule. In addition, novel autoantibodies that target the nervous system have been found in patients with encephalitis and neurological disorders. Some of these autoantibodies...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantibodies
Share to Calcium-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neural Cell Adhesion Molecules

Share to Phenotype

Share to Schizophrenia

Source

Identifiers

PMID: 37004758
DOI: 10.1016/j.bbi.2023.03.028

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analyzing schizophrenia-related phenotypes in mice caused by autoantibodies against NRXN1α in schizophrenia.PMID 37004758Read ↗

Autoantibodies against NCAM1 from patients with schizophrenia cause schizophrenia-related behavior and changes in synapses in miceSemantic proximity Read ↗

Identification and functional characterization of rare mutations of the neuroligin-2 gene (NLGN2) associated with schizophrenia.Semantic proximity Read ↗

NMDAR1 autoantibodies as potential biomarkers for schizophrenia phenotyping.Semantic proximity Read ↗

<i>In vivo</i> dissection of human <i>NRXN1</i> isoforms reveals gain-of-function pathogenicity of schizophrenia-associated 3’ deletionsSemantic proximity Read ↗

Heterozygous deletion of α-neurexin I or α-neurexin II results in behaviors relevant to autism and schizophrenia.Semantic proximity Read ↗

GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation.Semantic proximity Read ↗

Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic PatientsSemantic proximity Read ↗

Neuregulin-1 immunoreactivity in peripheral plasma is associated with rs6982890 polymorphism-mediated psychotic symptoms in schizophrenia.Semantic proximity Read ↗

Dynamic disorganization of synaptic NMDA receptors triggered by autoantibodies from psychotic patientsSemantic proximity Read ↗

Schizophrenia: A Pathogenetic Autoimmune Disease Caused by Viruses and Pathogens and Dependent on GenesSemantic proximity Read ↗

Overexpression of Neuregulin 1 Type III Confers Hippocampal mRNA Alterations and Schizophrenia-Like Behaviors in MiceSemantic proximity Read ↗

Neuregulin 1 promotes excitatory synapse development and function in GABAergic interneurons.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.