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Article

Pc2-mediated SUMOylation of WWOX is essential for its suppression of DU145 prostate tumorigenesis.

FEBS letters - 21 Dec 2015

Choi Hye-Jin, Park Jung-Hwan, Park Jong-Hwan, Lee Kyung Bok, Oh Sang-Muk

Abstract excerpt

Tumor suppressor WW domain-containing oxidoreductase (WWOX) is depleted in various cancer types. Here we report that WWOX is modified by small ubiquitin-like modifier (SUMO) proteins and represses DU145 prostate cancer tumorigenesis in a SUMOylation-dependent manner. Ectopic WWOX was shown to associate with SUMO2/3 or E2 Ubc9. Furthermore, we revealed that WWOX SUMOylation was promoted by E3 ligase polycomb2...

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Source

Identifiers

PMID: 26592150
DOI: 10.1016/j.febslet.2015.11.028

Genes

WWOX
SUMO2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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