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Article

Role of Desumoylation in the Development of Prostate Cancer

1 Aug 2006

Abstract excerpt

SUMO is a novel ubiquitin-like protein that can covalently modify a large number of nuclear proteins. SUMO modification has emerged as an important regulatory mechanism for protein function and localization. Sumoylation is a dynamic process that is mediated by activating (E1), conjugating (E2), and ligating (E3) enzymes and is readily reversed by a family of SUMO-specific proteases (SENPs). Since SUMO was...

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PMID: 16925949
DOI: 10.1593/neo.06445

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