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Article

Mutant p53 induces EZH2 expression and promotes epithelial-mesenchymal transition by disrupting p68-Drosha complex assembly and attenuating miR-26a processing.

Oncotarget - 29 Dec 2015

Jiang Fei-Zhou, He Yin-Yan, Wang Hui-Hui, Zhang Hui-Lin, Zhang Jian, Yan Xiao-Fang, Wang Xiao-Jun, Che Qi, Ke Jie-Qi, Chen Zheng, Tong Huan, Zhang Yong-Li, Wang Fang-Yuan, Li Yi-Ran, Wan Xiao-Ping

Abstract excerpt

The tumor suppressor p53 and the transcriptional repressor Enhancer of Zeste Homolog 2 (EZH2) have both been implicated in the regulation of epithelial-mesenchymal transition (EMT) and tumor metastasis via their impacts on microRNA expression. Here, we report that mutant p53 (mutp53) promotes EMT in endometrial carcinoma (EC) by disrupting p68-Drosha complex assembly. Overexpression of mutp53 has the opposite...

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Identifiers

PMID: 26587974
DOI: 10.18632/oncotarget.6350
PMCID: PMC4792583

Genes

MET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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