Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RACK1 cooperates with NRASQ61K to promote melanoma in vivo.

Cellular signalling - 1 Aug 2017

Campagne C, Reyes-Gomez E, Picco M E, Loiodice S, Salaun P, Ezagal J, Bernex F, Commère P H, Pons S, Esquerre D, Bourneuf E, Estellé J, Maskos U, Lopez-Bergami P, Aubin-Houzelstein G, Panthier J J, Egidy G

Abstract excerpt

Melanoma is the deadliest skin cancer. RACK1 (Receptor for activated protein kinase C) protein was proposed as a biological marker of melanoma in human and domestic animal species harboring spontaneous melanomas. As a scaffold protein, RACK1 is able to coordinate the interaction of key signaling molecules implicated in both physiological cellular functions and tumorigenesis. A role for RACK1 in rewiring ERK and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gain of Function Mutation

Share to JNK Mitogen-Activated Protein Kinases

Share to Melanocytes

Share to Melanoma, Experimental

Share to Neovascularization, Pathologic

Share to STAT3 Transcription Factor

Source

Identifiers

PMID: 28343944
DOI: 10.1016/j.cellsig.2017.03.015

Genes

RACK1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RACK1 cooperates with NRASQ61K to promote melanoma in vivo.PMID 28343944Read ↗

Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61K on an INK4a-Deficient BackgroundSemantic proximity Read ↗

RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy ResistanceSemantic proximity Read ↗

Somatic p16INK4a loss accelerates melanomagenesisSemantic proximity Read ↗

A Mouse Model of Melanoma Driven by Oncogenic KRASSemantic proximity Read ↗

A targetable PREX2/RAC1/PI3Kβ signalling axis confers resistance to clinically relevant therapeutic approaches in melanomaSemantic proximity Read ↗

RAC1 and melanoma.Semantic proximity Read ↗

Haplosufficiency of PAX3 for melanoma development in Tyr: NRASQ61K; Cdkn2a-/- mice allows identification and sorting of melanoma cells using a Pax3GFP reporter allele.Semantic proximity Read ↗

Targeting effector pathways in RAC1P29S-driven malignant melanoma.Semantic proximity Read ↗

C57BL/6 congenic mouse NRASQ61K melanoma cell lines are highly sensitive to the combination of Mek and Akt inhibitors in vitro and in vivoSemantic proximity Read ↗

Targeting the PREX2/RAC1/PI3Kβ Signaling Axis Confers Sensitivity to Clinically Relevant Therapeutic Approaches in Melanoma.Semantic proximity Read ↗

Carcinogen treatment in mouse selectively expressing activated N-Ras Q61K in melanocytes recapitulates metastatic cutaneous melanoma development.Semantic proximity Read ↗

The role of Rac1 in maintaining malignant phenotype of mouse skin tumor cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.