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Are acinic cell carcinomas of the breast and salivary glands distinct diseases?

Histopathology - 1 Oct 2015

Piscuoglio Salvatore, Hodi Zsolt, Katabi Nora, Guerini-Rocco Elena, Macedo Gabriel S, Ng Charlotte K Y, Edelweiss Marcia, De Mattos-Arruda Leticia, Wen Hannah Y, Rakha Emad A, Ellis Ian O, Rubin Brian P, Weigelt Britta, Reis-Filho Jorge S

Abstract excerpt

AIMS: Acinic cell carcinomas (AcCC) of the breast have been reported to constitute the breast counterpart of salivary gland AcCCs, based on the similarities of their histological and immunohistochemical features. Breast AcCC is a vanishingly rare form of triple-negative breast cancer (TNBC). Recent studies have demonstrated that in TNBCs, the two driver genes most frequently mutated are TP53 (82%) and PIK3CA...

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Identifiers

PMID: 25688711
DOI: 10.1111/his.12673
PMCID: PMC5006393

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