Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells.

Cancer research - 1 Jul 2008

Stohr Bradley A, Blackburn Elizabeth H

Abstract excerpt

Telomeres are elongated by the enzyme telomerase, which contains a template-bearing RNA (TER or TERC) and a protein reverse transcriptase. Overexpression of a particular mutant human TER with a mutated template sequence (MT-hTer-47A) in telomerase-positive cancer cells causes incorporation of mutant telomeric sequences, telomere uncapping, and initiation of a DNA damage response, ultimately resulting in cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to Gene Fusion
Share to Repetitive Sequences, Nucleic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to RNA, Small Interfering

Share to Telomerase

Share to Telomere

Share to Transgenes

Share to Tumor Stem Cell Assay

Source

Open in PubMed Open full text

Identifiers

PMID: 18593932
DOI: 10.1158/0008-5472.CAN-08-0504
PMCID: PMC2553270

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

ATM mediates cytotoxicity of a mutant telomerase RNA in human cancer cells.PMID 18593932Read ↗

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to TelomeresSemantic proximity Read ↗

Haploinsufficiency of hTERT leads to telomere dysfunction and radiosensitivity in human cancer cells.Semantic proximity Read ↗

Telomerase-independent Regulation of ATR by Human Telomerase RNASemantic proximity Read ↗

Targeting the Limitless Replicative Potential of Cancer: The Telomerase/Telomere PathwaySemantic proximity Read ↗

Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitorsSemantic proximity Read ↗

Telomerase reverse transcriptase expression protects transformed human cells against DNA-damaging agents, and increases tolerance to chromosomal instability.Semantic proximity Read ↗

Multiple roles of ATM in monitoring and maintaining DNA integritySemantic proximity Read ↗

A novel telomerase substrate precursor rapidly induces telomere dysfunction in telomerase positive cancer cells but not telomerase silent normal cellsSemantic proximity Read ↗

In perspective: An update on telomere targeting in cancerSemantic proximity Read ↗

ATRX loss induces multiple hallmarks of the alternative lengthening of telomeres (ALT) phenotype in human glioma cell lines in a cell line-specific mannerSemantic proximity Read ↗

A long noncoding RNA sensitizes genotoxic treatment by attenuating ATM activation and homologous recombination repair in cancersSemantic proximity Read ↗

ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral TherapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.