Article
The γ-Protocadherins Interact Physically and Functionally with Neuroligin-2 to Negatively Regulate Inhibitory Synapse Density and Are Required for Normal Social Interaction.
Molecular neurobiology - 1 Jun 2021
Steffen David M, Ferri Sarah L, Marcucci Charles G, Blocklinger Kelsey L, Molumby Michael J, Abel Ted, Weiner Joshua A
Abstract excerpt
Cell adhesion molecules (CAMs) are key players in the formation of neural circuits during development. The γ-protocadherins (γ-Pcdhs), a family of 22 CAMs encoded by the Pcdhg gene cluster, are known to play important roles in dendrite arborization, axon targeting, and synapse development. We showed previously that multiple γ-Pcdhs interact physically with the autism-associated CAM neuroligin-1, and inhibit the...
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