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Article

Functional role of the conserved proline in helix 6 of the human bradykinin B2 receptor.

Biochemical and biophysical research communications - 22 Feb 2008

Haffemayer Benjamin, Richard Eric, Mattras Hélène, Marie Jacky

Abstract excerpt

Pro258 in transmembrane domain (TMD) 6 of the bradykinin (BK) B(2) receptor (B(2)R) is highly conserved among G-protein coupled receptors (GPCRs). Using mutagenesis, we show that Pro258 is required for normal trafficking of the receptor to the plasma membrane and that mutation of Pro258 to Ala or Leu but not Gly, enhances BK efficacy to induce receptor activation. Furthermore, P258A mutation suppresses the...

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Identifiers

PMID: 18096516
DOI: 10.1016/j.bbrc.2007.12.069

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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