Article
TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice.
Gastroenterology - 1 Mar 2016
Uthaya Kumar Dinesh Babu, Chen Chia-Lin, Liu Jian-Chang, Feldman Douglas E, Sher Linda S, French Samuel, DiNorcia Joseph, French Samuel W, Naini Bita V, Junrungsee Sunhawit, Agopian Vatche Garen, Zarrinpar Ali, Machida Keigo
Abstract excerpt
BACKGROUND & AIMS: Obesity and alcohol consumption contribute to steatohepatitis, which increases the risk for hepatitis C virus (HCV)-associated hepatocellular carcinomas (HCCs). Mouse hepatocytes that express HCV-NS5A in liver up-regulate the expression of Toll-like receptor 4 (TLR4), and develop liver tumors containing tumor-initiating stem-like cells (TICs) that express NANOG. We investigated whether the TLR4...
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