Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Progenitor/stem cells give rise to liver cancer due to aberrant TGF-β and IL-6 signaling

8 Feb 2008

Abstract excerpt

Cancer stem cells (CSCs) are critical for the initiation, propagation, and treatment resistance of multiple cancers. Yet functional interactions between specific signaling pathways in solid organ "cancer stem cells," such as those of the liver, remain elusive. We report that in regenerating human liver, two to four cells per 30,000-50,000 cells express stem cell proteins Stat3, Oct4, and Nanog, along with the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to FOXO transcription factor regulation
Share to Liver physiology and pathology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18263735
DOI: 10.1073/pnas.0705395105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Progenitor/stem cells give rise to liver cancer due to aberrant TGF-β and IL-6 signalingPMID 18263735Read ↗

Transforming growth factor‐β in liver cancer stem cells and regenerationSemantic proximity Read ↗

Activation of IL6/IGFIR Confers Poor Prognosis of HBV-Related Hepatocellular Carcinoma through Induction of OCT4/NANOG ExpressionSemantic proximity Read ↗

Cancer stem cells in the development of liver cancer.Semantic proximity Read ↗

Emerging Regulatory Mechanisms Involved in Liver Cancer Stem Cell Properties in Hepatocellular CarcinomaSemantic proximity Read ↗

Molecular Biology of Liver Cancer Stem CellsSemantic proximity Read ↗

The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer.Semantic proximity Read ↗

TGF-β serves as a critical signaling determinant of liver progenitor cell fate and functionSemantic proximity Read ↗

HLF transactivates TFEB to promote gallbladder cancer stem cells’ self-renewal and determines tumor response to distinct therapiesSemantic proximity Read ↗

Expression profiles of stemness genes in gastrointestinal stromal tumor.Semantic proximity Read ↗

Transforming Growth Factor-β Signaling in Stem Cells and CancerSemantic proximity Read ↗

Orchestration of hepatocellular carcinoma development by diverse liver cancer stem cellsSemantic proximity Read ↗

Inflammatory cytokines promote the retrodifferentiation of tumor-derived hepatocyte-like cells to progenitor cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.