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DNA EXCISION REPAIR

1 Jun 1996

Abstract excerpt

In nucleotide excision repair DNA damage is removed through incision of the damaged strand on both sides of the lesion, followed by repair synthesis, which fills the gap using the intact strand as a template, and finally ligation. In prokaryotes the damaged base is removed in a 12-13 nucleotide (nt)-long oligomer; in eukaryotes including humans the damage is excised in a 24-32 nt-long fragment. Excision in...

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PMID: 8811174
DOI: 10.1146/annurev.bi.65.070196.000355

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