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Article

Costimulatory and coinhibitory receptors in anti‐tumor immunity

21 Apr 2009

Abstract excerpt

SUMMARY: Despite the expression of antigens by tumor cells, spontaneous immune-mediated rejection of cancer seems to be a rare event. T-cell receptor engagement by peptide/major histocompatibility complexes constitutes the main signal for the activation of naive T cells but is not sufficient to initiate a productive generation and maintenance of effector cells. Full activation of T cells requires additional...

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PMID: 19426219
DOI: 10.1111/j.1600-065x.2009.00771.x

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