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Article

Monitoring EGFR T790M with plasma DNA from lung cancer patients in a prospective observational study.

Cancer science - 1 Feb 2016

Sueoka-Aragane Naoko, Katakami Nobuyuki, Satouchi Miyako, Yokota Soichiro, Aoe Keisuke, Iwanaga Kentaro, Otsuka Kojiro, Morita Satoshi, Kimura Shinya, Negoro Shunichi

Abstract excerpt

Use of plasma DNA to detect mutations has spread widely as a form of liquid biopsy. EGFR T790M has been observed in half of lung cancer patients who have acquired resistance to EGFR tyrosine kinase inhibitors (EGFR-TKI). Effectiveness of monitoring T790M via plasma DNA during treatment with EGFR-TKI has not been established as an alternative to re-biopsy. This was a prospective multicenter observational study...

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Identifiers

PMID: 26577492
DOI: 10.1111/cas.12847
PMCID: PMC4768390

Genes

EGFR
MBP

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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